Hi , you don't need to dilute the solution itself, as you will be adding the drops to water before you take them anyway, so in effect you will be diluting it. I found it best to split my dose, I take 4 drops in the morning on an empty stomach, and 4 in the evening before I go to bed. It is a very individual thing though, but it is important to take the Iodine on its own, not with the companion supps.
I don't see any reason why you couldn't start the Iodine as soon as you get it, but the companion supps are important, so it would be a good idea to start them as soon as you get them.
If you do start getting detox symptoms, there is a lot of info on this forum about how to deal with this. Some people pulse the dose, some use salt water flushes, and some like me, just up the dose to 100mg per day, and push through it.
I started noticing changes with breast soreness and shrinking of breast cysts, after about 3-4 weeks, and after 6 months the FBD was pretty much gone, and after about 9 months, I had no uterine fibroids or FBD.