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No one knows what causes brain tumors; there are only a few known risk factors that have been established by research.
Children who receive radiation to the head have a higher risk of developing a brain tumor as adults, as do people who have certain rare genetic conditions such as neurofibromatosis or Li-Fraumeni syndrome. But those cases represent a fraction of the approximately 35,000 new primary brain tumors diagnosed each year. Age is also a risk factor -- people over the age of 65 are diagnosed with brain cancer at a rate four times higher than younger people.
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